bicd-1 Protein bicaudal D homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bicd-1
Official Full Name: Protein bicaudal D homolog
Primary source: WormBase:WBGene00016611
Locus tag: CELE_C43G2.2
See related: AllianceGenome:WB:WBGene00016611
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynactin binding activity and dynein complex binding activity. Involved in regulation of dendrite morphogenesis. Located in dendrite and neuronal cell body. Is expressed in several structures, including excretory cell; hypodermal cell; neurons; non-striated muscle; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominant 2A and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to several human genes including BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bicd-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (6565377..6572338, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data describe a novel role for bicd-1 in regulating dendrite branch formation and show that bicd-1 is likely to be expressed, and primarily required, in PVD neurons to control dendritic branching.
Title: C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C43G2.2 (e-PCR)
- UniSTS:313858

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytoskeletal anchor activity	IEA Inferred from Electronic Annotation more info
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule anchoring at microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in protein localization to organelle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein bicaudal D homolog

NP_001293734.1

Confirmed by transcript evidence

NP_001293735.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6565377..6572338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306806.4 → NP_001293735.1 Protein bicaudal D homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293735.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CK55

Conserved Domains (2) summary

COG1196
Location:2 → 174

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09730
Location:97 → 679

BicD; Microtubule-associated protein Bicaudal-D
NM_001306805.2 → NP_001293734.1 Protein bicaudal D homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

V6CJ04, V6CK55

Conserved Domains (2) summary

COG1196
Location:2 → 174

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09730
Location:97 → 679

BicD; Microtubule-associated protein Bicaudal-D