adh-1 Alcohol dehydrogenase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: adh-1
Official Full Name: Alcohol dehydrogenase 1
Primary source: WormBase:WBGene00010790
Locus tag: CELE_K12G11.3
See related: AllianceGenome:WB:WBGene00010790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alcohol dehydrogenase (NAD+) activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in cytoplasm. Is expressed in several structures, including body wall musculature; distal tip cell; intestine; muscle cell; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See adh-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (11888248..11889650)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased alcohol dehydrogenase 1 activity promotes longevity.
Title: Increased alcohol dehydrogenase 1 activity promotes longevity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K12G11.3 (e-PCR)
- UniSTS:321587

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alcohol dehydrogenase 1

NP_505991.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11888248..11889650

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073590.8 → NP_505991.1 Alcohol dehydrogenase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505991.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45688, Q17334

Conserved Domains (2) summary

cd08297
Location:9 → 347

CAD3; Cinnamyl alcohol dehydrogenases (CAD)

COG1064
Location:6 → 348

AdhP; D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family [Carbohydrate transport and metabolism]