sym-2 RNA-binding protein sym-2;RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sym-2
Official Full Name: RNA-binding protein sym-2;RRM domain-containing protein
Primary source: WormBase:WBGene00006367
Locus tag: CELE_ZK1067.6
See related: AllianceGenome:WB:WBGene00006367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sym-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (9178514..9188480, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy.
Title: Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1067.6 (e-PCR)
- UniSTS:319821

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal movement	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein sym-2;RRM domain-containing protein

NP_001300608.1

Partially confirmed by transcript evidence

NP_495960.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9178514..9188480 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063559.10 → NP_495960.2 RNA-binding protein sym-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495960.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22708, Q23391, Q86GJ8

Conserved Domains (4) summary

COG0724
Location:282 → 446

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12507
Location:182 → 256

RRM1_ESRPs_Fusilli; RNA recognition motif 1 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cd12508
Location:281 → 355

RRM2_ESRPs_Fusilli; RNA recognition motif 2 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cd12743
Location:388 → 472

RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
NM_001313679.3 → NP_001300608.1 RRM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARR9

Conserved Domains (2) summary

cd12508
Location:9 → 83

RRM2_ESRPs_Fusilli; RNA recognition motif 2 in epithelial splicing regulatory protein ESRP1, ESRP2, Drosophila RNA-binding protein Fusilli and similar proteins

cl17169
Location:116 → 200

RRM_SF; RNA recognition motif (RRM) superfamily