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    aat-3 Large neutral amino acids transporter small subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 180557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aat-3
    Official Full Name
    Large neutral amino acids transporter small subunit 1
    Primary source
    WormBase:WBGene00000004
    Locus tag
    CELE_F52H2.2
    See related
    AllianceGenome:WB:WBGene00000004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aat-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (2552260..2557736)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sodium-dependent multivitamin transporter Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peptidase_M10 domain-containing protein Neighboring gene Diminuto-like protein;FAD-binding PCMH-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. Caito SW, et al. Biochem Biophys Res Commun, 2013 Jun 14. PMID 23669041, Free PMC Article
    2. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Arantes LP, et al. Toxicol Res (Camb), 2016 Nov 1. PMID 28316775, Free PMC Article
    3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
    4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of amino acid transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Large neutral amino acids transporter small subunit 1
    NP_001300351.1
    • Confirmed by transcript evidence
    NP_508461.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2552260..2557736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313422.5 → NP_001300351.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVL7
      Conserved Domains (1) summary
      TIGR00911
      Location:40 → 527
      2A0308; L-type amino acid transporter

    2. NM_076060.7 → NP_508461.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17395
      Conserved Domains (1) summary
      TIGR00911
      Location:4 → 491
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version

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