chw-1 CHp/Wrch Rho-like protein homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: chw-1
Official Full Name: CHp/Wrch Rho-like protein homolog
Primary source: WormBase:WBGene00009059
Locus tag: CELE_F22E12.2
See related: AllianceGenome:WB:WBGene00009059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in establishment or maintenance of cell polarity and vulval development. Predicted to be active in plasma membrane. Is expressed in several structures, including P3.p hermaphrodite; P3.pa; P3.pp; P4.p hermaphrodite; and P8.p hermaphrodite. Orthologous to several human genes including RHOU (ras homolog family member U). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See chw-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (10462282..10464660)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that chw-1 is likely acting downstream and/or in parallel to sax-3 in axon guidance.
Title: The Atypical Rho GTPase CHW-1 Works with SAX-3/Robo To Mediate Axon Guidance in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F22E12.2 (e-PCR)
- UniSTS:320051

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vulval development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CHp/Wrch Rho-like protein homolog

NP_505686.1

Product from WormBase gene class chw;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10462282..10464660

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073285.2 → NP_505686.1 CHp/Wrch Rho-like protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505686.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19739

Conserved Domains (2) summary

cd04130
Location:10 → 172

Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

smart00174
Location:12 → 174

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases