sptl-1 Serine palmitoyltransferase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sptl-1
Official Full Name: Serine palmitoyltransferase 1
Primary source: WormBase:WBGene00016020
Locus tag: CELE_C23H3.4
See related: AllianceGenome:WB:WBGene00016020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable serine C-palmitoyltransferase activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Predicted to be active in endoplasmic reticulum. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A and juvenile amyotrophic lateral sclerosis type 27. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sptl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (51652..57570)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C23H3.4 (e-PCR)
- UniSTS:309129

C23H3.7 (e-PCR)
- UniSTS:312516

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables serine C-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine C-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine palmitoyltransferase 1

NP_001021979.1

Confirmed by transcript evidence

NP_001300513.1

Confirmed by transcript evidence

NP_001379707.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

51652..57570

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392983.1 → NP_001379707.1 Serine palmitoyltransferase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P91079, Q5R3Y5

Conserved Domains (1) summary

cl18945
Location:9 → 455

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001026808.4 → NP_001021979.1 Serine palmitoyltransferase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021979.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91079

Conserved Domains (2) summary

COG0156
Location:50 → 427

BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

cl18945
Location:13 → 431

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001313584.3 → NP_001300513.1 Serine palmitoyltransferase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARH7

Conserved Domains (1) summary

cl18945
Location:2 → 171

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...