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    C06A6.4 N-acyl-aliphatic-L-amino acid amidohydrolase [ Caenorhabditis elegans ]

    Gene ID: 177571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C06A6.4
    Official Full Name
    N-acyl-aliphatic-L-amino acid amidohydrolase
    Primary source
    WormBase:WBGene00015509
    Locus tag
    CELE_C06A6.4
    See related
    AllianceGenome:WB:WBGene00015509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminoacylase activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in cytoplasm. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C06A6.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (7826323..7829298, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MS Related Protein Neighboring gene ncRNA Neighboring gene Multivesicular body subunit 12A Neighboring gene Endoplasmic reticulum resident protein 44.2 Neighboring gene FTH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acyl-aliphatic-L-amino acid amidohydrolase
    NP_001021300.1
    • Confirmed by transcript evidence
    NP_001021301.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7826323..7829298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026130.9 → NP_001021301.1  N-acyl-aliphatic-L-amino acid amidohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRS4
      Conserved Domains (1) summary
      cd05646
      Location:3 → 408
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily

    2. NM_001026129.9 → NP_001021300.1  N-acyl-aliphatic-L-amino acid amidohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17686
      Conserved Domains (1) summary
      cd05646
      Location:3 → 394
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily

    RNA

    1. NR_131576.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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