henn-1 Small RNA 2'-O-methyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: henn-1
Official Full Name: Small RNA 2'-O-methyltransferase
Primary source: WormBase:WBGene00015349
Locus tag: CELE_C02F5.6
See related: AllianceGenome:WB:WBGene00015349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small RNA 2'-O-methyltransferase activity. Involved in RNA methylation; piRNA processing; and siRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Is expressed in germ line and somatic cell. Orthologous to human HENMT1 (HEN methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See henn-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (8232651..8234611)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-169 (e-PCR)
- UniSTS:242011

C02F5.6 (e-PCR)
- UniSTS:308431

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables small RNA 2'-O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables small RNA 2'-O-methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Small RNA 2'-O-methyltransferase

NP_001309472.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8232651..8234611

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322688.3 → NP_001309472.1 Small RNA 2'-O-methyltransferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P34283, Q8T3F9

Conserved Domains (1) summary

cl25638
Location:74 → 280

Hen1_L; RNA repair, ligase-Pnkp-associating, region of Hen1