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    H06I04.3 Putative rRNA methyltransferase;rRNA methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 175414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H06I04.3
    Official Full Name
    Putative rRNA methyltransferase;rRNA methyltransferase
    Primary source
    WormBase:WBGene00019168
    Locus tag
    CELE_H06I04.3
    See related
    AllianceGenome:WB:WBGene00019168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See H06I04.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (3070523..3085268)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ubiquitin-like protein 1 Neighboring gene ncRNA Neighboring gene SURF1-like protein Neighboring gene uncharacterized protein Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative rRNA methyltransferase;rRNA methyltransferase
    NP_001022635.1
    • Confirmed by transcript evidence
    NP_497655.1
    • Confirmed by transcript evidence
    NP_497656.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3070523..3085268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065254.8 → NP_497655.1  Putative rRNA methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5N9
      Conserved Domains (3) summary
      COG0293
      Location:8 → 197
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
      pfam07780
      Location:618 → 800
      Spb1_C; Spb1 C-terminal domain
      pfam11861
      Location:237 → 368
      DUF3381; Domain of unknown function (DUF3381)

    2. NM_001027464.6 → NP_001022635.1  Putative rRNA methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5CCJ2
      Conserved Domains (3) summary
      COG0293
      Location:8 → 197
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
      pfam07780
      Location:618 → 786
      Spb1_C; Spb1 C-terminal domain
      pfam11861
      Location:237 → 368
      DUF3381; Domain of unknown function (DUF3381)

    3. NM_065255.6 → NP_497656.2  rRNA methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497656.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5CCJ3
      Conserved Domains (3) summary
      COG0293
      Location:8 → 197
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
      pfam07780
      Location:618 → 716
      Spb1_C; Spb1 C-terminal domain
      pfam11861
      Location:237 → 368
      DUF3381; Domain of unknown function (DUF3381)
    Nucleotide Protein
    Heading Accession and Version

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