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    Y106G6D.5 Helicase ATP-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 13181740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y106G6D.5
    Official Full Name
    Helicase ATP-binding domain-containing protein
    Primary source
    WormBase:WBGene00014965
    Locus tag
    CELE_Y106G6D.5
    See related
    AllianceGenome:WB:WBGene00014965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y106G6D.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (10119187..10122171, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Myb-like protein X Neighboring gene Protein kinase domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription termination site sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Helicase ATP-binding domain-containing protein
    NP_001300390.1
    • Confirmed by transcript evidence
    NP_001370940.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10119187..10122171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313461.3 → NP_001300390.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K2WNK1
      Conserved Domains (3) summary
      TIGR00376
      Location:55 → 653
      TIGR00376; DNA helicase, putative
      pfam13087
      Location:435 → 632
      AAA_12; AAA domain
      pfam13245
      Location:228 → 294
      AAA_19; Part of AAA domain

    2. NM_001383712.1 → NP_001370940.1  Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K2WN06
      Conserved Domains (2) summary
      COG1112
      Location:144 → 563
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam13087
      Location:344 → 541
      AAA_12; AAA domain

    RNA

    1. NR_132563.1 RNA Sequence

      Status: REVIEWED

    2. NR_132564.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials