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    clc-1 Claudin [ Caenorhabditis elegans ]

    Gene ID: 181293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clc-1
    Official Full Name
    Claudin
    Primary source
    WormBase:WBGene00000522
    Locus tag
    CELE_C09F12.1
    See related
    AllianceGenome:WB:WBGene00000522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-positive bacterium; epithelial cell-cell adhesion; and innate immune response. Located in cell-cell junction. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (11047446..11049275)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene LIM domain-binding protein 1;LIM interaction domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycosyltransferase 2-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probiotic-mediated p38 MAPK immune signaling prolongs the survival of Caenorhabditis elegans exposed to pathogenic bacteria. Dinić M, et al. Sci Rep, 2021 Oct 28. PMID 34711881, Free PMC Article
    2. Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel. Yamada T, et al. Biophys J, 2016 Nov 1. PMID 27806269, Free PMC Article
    3. Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium. Asano A, et al. Curr Biol, 2003 Jun 17. PMID 12814550
    4. Claudin family proteins in Caenorhabditis elegans. Simske JS, et al. Methods Mol Biol, 2011. PMID 21717355
    5. RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation. Jensen VL, et al. PLoS One, 2010 Dec 31. PMID 21209831, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the roles of CLC Bateman domains and the structure-function relationships that govern the regulation of CLC protein activity
      Title: Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Claudin
    NP_509847.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11047446..11049275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077446.6 → NP_509847.1  Claudin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93198
      Conserved Domains (1) summary
      pfam06653
      Location:96 → 182
      Claudin_3; Tight junction protein, Claudin-like
    Nucleotide Protein
    Heading Accession and Version

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