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    dlgr-1 NET domain-containing protein;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dlgr-1
    Official Full Name
    NET domain-containing protein;Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00020970
    Locus tag
    CELE_W03A5.6
    See related
    AllianceGenome:WB:WBGene00020970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be active in glutamatergic synapse and postsynaptic specialization. Orthologous to several human genes including DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dlgr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (5431379..5440640, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene J domain-containing protein Neighboring gene DM2 domain-containing protein Neighboring gene DIS3-like exonuclease 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NET domain-containing protein;Protein kinase domain-containing protein
    NP_001337303.1
    • Confirmed by transcript evidence
    NP_001337304.1
    • Partially confirmed by transcript evidence
    NP_498156.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5431379..5440640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350343.3 → NP_001337303.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUK8
      Conserved Domains (1) summary
      pfam03359
      Location:444 → 586
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_001350344.3 → NP_001337304.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HV05
      Conserved Domains (1) summary
      pfam03359
      Location:446 → 588
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_065755.5 → NP_498156.1  NET domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23138
      Conserved Domains (1) summary
      pfam03359
      Location:147 → 286
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein
    Heading Accession and Version

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