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    sin-3 Paired amphipathic helix protein sin-3 [ Caenorhabditis elegans ]

    Gene ID: 172628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sin-3
    Official Full Name
    Paired amphipathic helix protein sin-3
    Primary source
    WormBase:WBGene00004117
    Locus tag
    CELE_F02E9.4
    See related
    AllianceGenome:WB:WBGene00004117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to histone deacetylase activity. Involved in several processes, including cell fate specification; nematode male tail mating organ morphogenesis; and vulval development. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Predicted to be located in chromatin. Predicted to be part of Sin3-type complex. Is expressed in excretory cell; intestine; nervous system; pharynx; and ray structural cell. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sin-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    20
    Sequence:
    Chromosome: I; NC_003279.8 (8416816..8425051)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein yippee-like Neighboring gene Protein lin-28 Neighboring gene Tartrate-resistant acid phosphatase type 5 Neighboring gene Oxidative stress-responsive serine-rich protein 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Dipeptidyl peptidase 3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux. Giovannetti M, et al. iScience, 2024 May 17. PMID 38746662, Free PMC Article
    2. ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans. Sharma M, et al. Autophagy, 2018. PMID 29912629, Free PMC Article
    3. SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans. Pandey R, et al. Aging (Albany NY), 2018 Dec 12. PMID 30541942, Free PMC Article
    4. Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation. Konwar C, et al. J Gerontol A Biol Sci Med Sci, 2024 Sep 1. PMID 38894529
    5. Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans. Beurton F, et al. Nucleic Acids Res, 2019 Dec 2. PMID 31602465, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
      Title: Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.
      Title: SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.
    3. Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development.
      Title: Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development.
    4. The results suggest that genetic perturbation along with the gender play an important role in determining the lifespan, healthspan and overall fitness of an organism.
      Title: SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans.
    5. SIN-3 differentially modulates autophagy and lifespan.
      Title: ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.
    6. SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development
      Title: C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to other organism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Paired amphipathic helix protein sin-3
    NP_001122442.1
    • Confirmed by transcript evidence
    NP_492284.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8416816..8425051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059883.8 → NP_492284.2  Paired amphipathic helix protein sin-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492284.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5JYW9
      Conserved Domains (4) summary
      smart00761
      Location:801 → 900
      HDAC_interact; Histone deacetylase (HDAC) interacting
      COG5602
      Location:271 → 1065
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:306 → 349
      PAH; Paired amphipathic helix repeat
      pfam16879
      Location:1144 → 1339
      Sin3a_C; C-terminal domain of Sin3a protein

    2. NM_001128970.5 → NP_001122442.1  Paired amphipathic helix protein sin-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5JYW9, O01319
      Conserved Domains (4) summary
      smart00761
      Location:801 → 900
      HDAC_interact; Histone deacetylase (HDAC) interacting
      COG5602
      Location:271 → 1062
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:306 → 349
      PAH; Paired amphipathic helix repeat
      pfam16879
      Location:1146 → 1341
      Sin3a_C; C-terminal domain of Sin3a protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5JYW9.1

    Gene LinkOut

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