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    acs-17 long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

    Gene ID: 180859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-17
    Official Full Name
    long-chain-fatty-acid--CoA ligase
    Primary source
    WormBase:WBGene00016716
    Locus tag
    CELE_C46F4.2
    See related
    AllianceGenome:WB:WBGene00016716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-17 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (5937558..5944499, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene EB domain-containing protein Neighboring gene Nucleoside-diphosphatase mig-23 Neighboring gene VWFA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis. Tang H, et al. Cell Rep, 2021 Aug 17. PMID 34407398, Free PMC Article
    2. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Jo H, et al. Cell Metab, 2009 May. PMID 19416714
    3. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
    4. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
    5. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, et al. Nature, 2003 Jul 17. PMID 12845331

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase
    NP_001360705.1
    • Partially confirmed by transcript evidence
    NP_508993.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5937558..5944499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373312.4 → NP_001360705.1  long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ING4
      Conserved Domains (1) summary
      cd17639
      Location:133 → 708
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    2. NM_076592.10 → NP_508993.2  long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508993.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18660
      Conserved Domains (2) summary
      cd05927
      Location:133 → 717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:78 → 717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein
    Nucleotide Protein
    Heading Accession and Version

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