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    ifc-2 IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2 [ Caenorhabditis elegans ]

    Gene ID: 180414, updated on 9-Dec-2024

    Summary

    Official Symbol
    ifc-2
    Official Full Name
    IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2
    Primary source
    WormBase:WBGene00002056
    Locus tag
    CELE_M6.1
    See related
    AllianceGenome:WB:WBGene00002056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in post-embryonic digestive tract morphogenesis. Located in cytoplasm and desmosome. Is expressed in several structures, including excretory cell; intestine; pharynx; rectal valve cell; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; Meesmann corneal dystrophy 2; epidermolysis bullosa simplex (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT1 (keratin 1); KRT10 (keratin 10); and KRT2 (keratin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ifc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    24
    Sequence:
    Chromosome: X; NC_003284.9 (642156..654904, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Galectin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LiPocalin-Related protein Neighboring gene RUN domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cytoskeleton organization  
    involved_in heterochromatin formation  
    involved_in nuclear envelope organization  
    involved_in nuclear migration  
    involved_in nuclear pore localization  
    involved_in post-embryonic digestive tract morphogenesis PubMed 
    involved_in protein localization to nuclear envelope  
    Component Evidence Code Pubs
    located_in cell junction PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in desmosome PubMed 
    located_in intermediate filament  
    is_active_in nuclear envelope  
    is_active_in nuclear lamina  

    General protein information

    Preferred Names
    IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2
    NP_001256975.1
    • Confirmed by transcript evidence
    NP_001362085.1
    • Confirmed by transcript evidence
    NP_001367765.1
    • Confirmed by transcript evidence
    NP_001379332.1
    • Product from WormBase gene class ifc;
      Partially confirmed by transcript evidence
    NP_001379874.1
    • Confirmed by transcript evidence
    NP_001380259.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      642156..654904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380893.1 → NP_001367765.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00038
      Location:690 → 1033
      Filament; Intermediate filament protein
    2. NM_001270046.2 → NP_001256975.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02366, Q21067, Q21579, Q21580
      UniProtKB/TrEMBL
      G8JY94
      Conserved Domains (2) summary
      pfam00038
      Location:51 → 394
      Filament; Intermediate filament protein
      cl01090
      Location:318 → 387
      SlyX; SlyX
    3. NM_001374936.2 → NP_001362085.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4LYE2
      Conserved Domains (1) summary
      pfam00038
      Location:768 → 1111
      Filament; Intermediate filament protein
    4. NM_001392718.1 → NP_001379874.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00038
      Location:690 → 1033
      Filament; Intermediate filament protein
    5. NM_001392719.1 → NP_001380259.1  IF rod domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4M3F7
      Conserved Domains (1) summary
      pfam00038
      Location:51 → 394
      Filament; Intermediate filament protein
    6. NM_001392720.1 → NP_001379332.1  Intermediate Filament, C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7I9BEY5
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