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    unc-82 Protein kinase domain-containing protein;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 177514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-82
    Official Full Name
    Protein kinase domain-containing protein;non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00006814
    Locus tag
    CELE_B0496.3
    See related
    AllianceGenome:WB:WBGene00006814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of muscle. Involved in striated muscle myosin thick filament assembly and striated muscle paramyosin thick filament assembly. Located in M band. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-82 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    36
    Sequence:
    Chromosome: IV; NC_003282.8 (7424498..7444664)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene LIM zinc-binding domain-containing protein Neighboring gene ncRNA Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UNC-82/NUAK kinase is required by myosin A, but not myosin B, to assemble and function in the thick filament arms of C. elegans striated muscle. Schiller NR, et al. Cytoskeleton (Hoboken), 2024 Dec. PMID 37983932
    2. Assemblages of multiple thick filaments in nematode mutants. Epstein HF, et al. J Muscle Res Cell Motil, 1987 Dec. PMID 3443685
    3. Sequences in the myosin A rod interact with UNC-89/obscurin and the zinc-finger protein UNC-98 during thick filament assembly and M-line formation in C. elegans striated muscle. Almuhanna SA, et al. Cytoskeleton (Hoboken), 2024 Dec. PMID 38400829
    4. The Role of the UNC-82 Protein Kinase in Organizing Myosin Filaments in Striated Muscle of Caenorhabditis elegans. Schiller NR, et al. Genetics, 2017 Mar. PMID 28040740, Free PMC Article
    5. Caenorhabditis elegans unc-82 encodes a serine/threonine kinase important for myosin filament organization in muscle during growth. Hoppe PE, et al. Genetics, 2010 Jan. PMID 19901071, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UNC-82 acts upstream of UNC-98/ZnF in a pathway that organizes paramyosin during thick filament assembly.
      Title: The Role of the UNC-82 Protein Kinase in Organizing Myosin Filaments in Striated Muscle of Caenorhabditis elegans.
    2. first report establishing a role for the UNC-82/ARK5/SNARK kinases in normal development
      Title: Caenorhabditis elegans unc-82 encodes a serine/threonine kinase important for myosin filament organization in muscle during growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in striated muscle myosin thick filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in striated muscle paramyosin thick filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;non-specific serine/threonine protein kinase
    NP_001255294.1
    • Confirmed by transcript evidence
    NP_001255295.1
    • Confirmed by transcript evidence
    NP_001255298.1
    • Confirmed by transcript evidence
    NP_001294207.1
    • Confirmed by transcript evidence
    NP_001359805.1
    • Confirmed by transcript evidence
    NP_001367366.1
    • Confirmed by transcript evidence
    NP_001367367.1
    • Confirmed by transcript evidence
    NP_001379584.1
    • Confirmed by transcript evidence
    NP_501186.5
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7424498..7444664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268365.3 → NP_001255294.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA5
      Conserved Domains (1) summary
      cd14073
      Location:295 → 548
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    2. NM_001380325.1 → NP_001367367.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA7
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    3. NM_001380324.1 → NP_001367366.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1MN54
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    4. NM_001372869.1 → NP_001359805.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA6
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    5. NM_001268369.2 → NP_001255298.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA8
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    6. NM_068785.7 → NP_501186.5  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501186.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1MN51
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    7. NM_001268366.4 → NP_001255295.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA9
      Conserved Domains (1) summary
      cd14073
      Location:56 → 309
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    8. NM_001307278.3 → NP_001294207.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RYB3
      Conserved Domains (1) summary
      cd14073
      Location:73 → 326
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    9. NM_001392329.1 → NP_001379584.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYA4
    Nucleotide Protein
    Heading Accession and Version

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