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    syg-2 Nephrin;Synaptogenesis protein syg-2 [ Caenorhabditis elegans ]

    Gene ID: 181561, updated on 9-Dec-2024

    Summary

    Official Symbol
    syg-2
    Official Full Name
    Nephrin;Synaptogenesis protein syg-2
    Primary source
    WormBase:WBGene00007750
    Locus tag
    CELE_C26G2.1
    See related
    AllianceGenome:WB:WBGene00007750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in cell-cell signaling; nervous system development; and protein localization to synapse. Predicted to be located in membrane and synapse. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including P6.p hermaphrodite; P6.pa; P6.paa; egg-laying apparatus; and neurons. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See syg-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    23
    Sequence:
    Chromosome: X; NC_003284.9 (14654968..14662865)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hyphal_reg_CWP domain-containing protein Neighboring gene ncRNA

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding  
    enables cell adhesion molecule binding PubMed 
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion  
    involved_in cell-cell adhesion  
    involved_in cell-cell signaling PubMed 
    involved_in collateral sprouting PubMed 
    involved_in nervous system development  
    involved_in protein localization to synapse PubMed 
    involved_in synapse assembly PubMed 
    involved_in synapse organization PubMed 
    involved_in synaptic target recognition PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    Nephrin;Synaptogenesis protein syg-2
    NP_001309467.1
    • Confirmed by transcript evidence
    NP_001309674.1
    • Confirmed by transcript evidence
    NP_001309675.1
    • Confirmed by transcript evidence
    NP_001309676.1
    • Confirmed by transcript evidence
    NP_001309677.1
    • Confirmed by transcript evidence
    NP_001309678.1
    • Confirmed by transcript evidence
    NP_001380194.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14654968..14662865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322664.3 → NP_001309467.1  Synaptogenesis protein syg-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3P2
      Conserved Domains (5) summary
      smart00408
      Location:743 → 804
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:735 → 815
      IG_like; Immunoglobulin like
      cd00063
      Location:921 → 1010
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:644 → 725
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:147 → 228
      Ig; Immunoglobulin domain
    2. NM_001322663.4 → NP_001309674.1  Synaptogenesis protein syg-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3P2
      UniProtKB/TrEMBL
      A0A131MB76
      Conserved Domains (5) summary
      smart00408
      Location:756 → 817
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:748 → 828
      IG_like; Immunoglobulin like
      cd00063
      Location:934 → 1023
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:657 → 738
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:147 → 228
      Ig; Immunoglobulin domain
    3. NM_001392890.1 → NP_001380194.1  Nephrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBZ2
      Conserved Domains (4) summary
      smart00408
      Location:441 → 502
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:619 → 708
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:132 → 136
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:128 → 222
      Ig; Immunoglobulin domain
    4. NM_001322665.4 → NP_001309678.1  Nephrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBS5
      Conserved Domains (5) summary
      smart00408
      Location:454 → 515
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:446 → 526
      IG_like; Immunoglobulin like
      cd00063
      Location:632 → 721
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:355 → 436
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:543 → 620
      Ig; Immunoglobulin domain
    5. NM_001322667.4 → NP_001309677.1  Synaptogenesis protein syg-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MDF3
      Conserved Domains (5) summary
      smart00408
      Location:275 → 336
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:267 → 347
      IG_like; Immunoglobulin like
      cd00063
      Location:453 → 542
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:176 → 257
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:364 → 441
      Ig; Immunoglobulin domain
    6. NM_001322668.4 → NP_001309676.1  Synaptogenesis protein syg-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCN5
      Conserved Domains (5) summary
      smart00408
      Location:246 → 307
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:238 → 318
      IG_like; Immunoglobulin like
      cd00063
      Location:424 → 513
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:147 → 228
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:335 → 412
      Ig; Immunoglobulin domain
    7. NM_001322669.4 → NP_001309675.1  Synaptogenesis protein syg-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBR9
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