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    Zfta zinc finger translocation associated [ Mus musculus (house mouse) ]

    Gene ID: 108899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zftaprovided by MGI
    Official Full Name
    zinc finger translocation associatedprovided by MGI
    Primary source
    MGI:MGI:1919667
    See related
    Ensembl:ENSMUSG00000053080 AllianceGenome:MGI:1919667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700081O15Rik
    Summary
    Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in forebrain. Orthologous to human ZFTA (zinc finger translocation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 43.0), CNS E14 (RPKM 41.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfta in Genome Data Viewer
    Location:
    19 A; 19 5.32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7394981..7403273)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7417625..7425908)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAB11B, member RAS oncogene family, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_45468 Neighboring gene predicted gene, 18842 Neighboring gene microRNA 6991 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7520209-7520392 Neighboring gene reticulon 3 Neighboring gene atlastin GTPase 3 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, et al. Acta Neuropathol Commun, 2021 Mar 8. PMID 33685520, Free PMC Article
    2. Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice. Herranz-Pérez V, et al. Sci Rep, 2022 Jan 27. PMID 35087169, Free PMC Article
    3. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice.
      Title: Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice.
    2. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
      Title: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger translocation-associated protein
    Names
    uncharacterized protein C11orf95 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401803.1 → NP_001388732.1  zinc finger translocation-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129188
      UniProtKB/TrEMBL
      A0A087WPN4

    2. NM_175381.7 → NP_780590.3  zinc finger translocation-associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC129188
      Consensus CDS
      CCDS29524.2
      UniProtKB/Swiss-Prot
      Q4VA45
      Related
      ENSMUSP00000123773.2, ENSMUST00000159348.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7394981..7403273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247115.3 → XP_011245417.1  zinc finger translocation-associated protein isoform X1

      Conserved Domains (1) summary
      pfam18658
      Location:638 → 705
      zf-C2H2_12; Zinc-finger C2H2-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VA45.2 GenPept UniProtKB/Swiss-Prot:Q4VA45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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