Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4f6provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily f, polypeptide 6provided by RGD
Primary source: RGD:708365
See related: EnsemblRapid:ENSRNOG00000043233 AllianceGenome:RGD:708365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in leukotriene metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 167.6), Kidney (RPKM 75.6) and 9 other tissues See more
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Genomic context

Location:: 7q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (12680799..12708378, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (12030276..12058020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (15198950..15225547, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study shows that traumatic brain injury (TBI) triggers inflammation and elicits changes in mRNA expression of CYP4Fs in the frontal and occipital lobes and the hippocampus.
Title: CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury.
CYP4Fs are regionally distributed in the spontaneously hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more highly expressed in the renal cortex than medulla while CYP4F6 shows higher medullary expression.
Title: Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats.
CYP4F5 and CYP4F6, due to their capacities to metabolize LTB(4), may play important roles in modulating inflammatory response in the lung and to some extent in the brain, kidney, and testis
Title: Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6.

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General gene information

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Markers

BF387205 (e-PCR)
- UniSTS:244254

RH138059 (e-PCR)
- UniSTS:220146

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in leukotriene metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4F6

Names: CYPIVF6

NP_695230.1

EC 1.14.14.1

XP_006241111.1

EC 1.14.14.1

XP_063119139.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153318.1 → NP_695230.1 cytochrome P450 4F6

See identical proteins and their annotated locations for NP_695230.1

Status: PROVISIONAL

Source sequence(s)

U39208

UniProtKB/Swiss-Prot

P51871

UniProtKB/TrEMBL

A6K973

Conserved Domains (1) summary

cd20679
Location:74 → 515

CYP4F; cytochrome P450 family 4, subfamily F