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    Btbd7 BTB domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd7provided by RGD
    Official Full Name
    BTB domain containing 7provided by RGD
    Primary source
    RGD:1306262
    See related
    EnsemblRapid:ENSRNOG00000008598 AllianceGenome:RGD:1306262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of branching involved in salivary gland morphogenesis. Predicted to be located in nucleus. Orthologous to human BTBD7 (BTB domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 160.6), Adrenal (RPKM 124.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd7 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127685185..127774947, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121920365..122010114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126658398..126748497, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lysosomal enzyme trafficking factor Neighboring gene GON7 subunit of KEOPS complex Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene unc-79 homolog, NALCN channel complex subunit Neighboring gene enolase 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice. Pan W, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527404
    2. Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Onodera T, et al. Science, 2010 Jul 30. PMID 20671187, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in morphogenesis of a branching epithelium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of branching involved in salivary gland morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 7
    Names
    BTB (POZ) domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108720.1 → NP_001102190.1  BTB/POZ domain-containing protein 7

      See identical proteins and their annotated locations for NP_001102190.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JEL7, D3ZCW2
      Related
      ENSRNOP00000062323.2, ENSRNOT00000064914.5
      Conserved Domains (4) summary
      smart00225
      Location:268 → 397
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:410 → 488
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:134 → 235
      BTB; BTB/POZ domain
      cl02518
      Location:269 → 393
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127685185..127774947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764818.4 → XP_008763040.1  BTB/POZ domain-containing protein 7 isoform X1

      See identical proteins and their annotated locations for XP_008763040.1

      UniProtKB/TrEMBL
      A0A0G2K9E3
      Related
      ENSRNOP00000074965.1, ENSRNOT00000081127.3
      Conserved Domains (4) summary
      smart00225
      Location:268 → 397
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:410 → 488
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:134 → 235
      BTB; BTB/POZ domain
      cl02518
      Location:269 → 393
      BTB; BTB/POZ domain

    2. XM_008764819.4 → XP_008763041.1  BTB/POZ domain-containing protein 7 isoform X1

      See identical proteins and their annotated locations for XP_008763041.1

      UniProtKB/TrEMBL
      A0A0G2K9E3
      Conserved Domains (4) summary
      smart00225
      Location:268 → 397
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:410 → 488
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:134 → 235
      BTB; BTB/POZ domain
      cl02518
      Location:269 → 393
      BTB; BTB/POZ domain

    3. XM_008764821.4 → XP_008763043.1  BTB/POZ domain-containing protein 7 isoform X2

      Conserved Domains (3) summary
      smart00225
      Location:143 → 230
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:134 → 235
      BTB; BTB/POZ domain
      cl02518
      Location:269 → 340
      BTB; BTB/POZ domain
    Nucleotide Protein Strain
    Heading Accession and Version

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