Gprc6a G protein-coupled receptor, class C, group 6, member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gprc6aprovided by RGD
Official Full Name: G protein-coupled receptor, class C, group 6, member Aprovided by RGD
Primary source: RGD:735077
See related: EnsemblRapid:ENSRNOG00000000401 AllianceGenome:RGD:735077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in regulation of testosterone biosynthetic process and response to amino acid. Located in plasma membrane. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31464818..31486121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30922106..30943412, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32607653..32628953, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPRC6A predominantly undergoes constitutive internalization with the early endosome marker Rab5 and the long loop recycling endosome marker Rab11 and to a much lesser extent with the late endosome marker Rab7
Title: The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.
cloning and characterization of rat GPRC6A
Title: The rat GPRC6A: cloning and characterization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of testosterone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor family C group 6 member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271106.1 → NP_001258035.1 G-protein coupled receptor family C group 6 member A precursor

See identical proteins and their annotated locations for NP_001258035.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q70VB1

UniProtKB/TrEMBL

A0A8I6G4E9, A6K472

Related

ENSRNOP00000000451.3, ENSRNOT00000000451.7

Conserved Domains (4) summary

cd06361
Location:37 → 506

PBP1_GPC6A_like; Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor

pfam00003
Location:605 → 838

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:75 → 482

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:520 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR