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    Pom121l2 POM121 transmembrane nucleoporin-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502128, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pom121l2provided by RGD
    Official Full Name
    POM121 transmembrane nucleoporin-like 2provided by RGD
    Primary source
    RGD:1594366
    See related
    EnsemblRapid:ENSRNOG00000061510 AllianceGenome:RGD:1594366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. Orthologous to human POM121L2 (POM121 transmembrane nucleoporin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 209.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pom121l2 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (47241917..47249231, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (42546144..42553447, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (44588022..44595347, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon CUG) 7 Neighboring gene transfer RNA serine (anticodon GCU) 11 Neighboring gene transfer RNA methionine (anticodon CAU) 7 Neighboring gene zinc finger protein 184 Neighboring gene Tu translation elongation factor, mitochondrial, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    POM121-like protein 2
    Names
    POM121 membrane glycoprotein-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162930.2 → NP_001156402.1  POM121-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001156402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KNA7
      Conserved Domains (1) summary
      pfam15229
      Location:162 → 341
      POM121; POM121 family

    2. NM_001162931.1 → NP_001156403.1  POM121-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC097347
      UniProtKB/TrEMBL
      D3ZGH9
      Related
      ENSRNOP00000070497.3, ENSRNOT00000086767.3
      Conserved Domains (1) summary
      pfam15229
      Location:162 → 341
      POM121; POM121 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      47241917..47249231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096031.2 → XP_038951959.1  POM121-like protein 2 isoform X5

    2. XM_039096030.2 → XP_038951958.1  POM121-like protein 2 isoform X4

    3. XM_017600654.3 → XP_017456143.1  POM121-like protein 2 isoform X2

    4. XM_006254111.5 → XP_006254173.1  POM121-like protein 2 isoform X1

      UniProtKB/TrEMBL
      D3ZGH9
      Conserved Domains (1) summary
      pfam15229
      Location:162 → 341
      POM121; POM121 family

    5. XM_006254112.5 → XP_006254174.1  POM121-like protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15229
      Location:162 → 341
      POM121; POM121 family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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