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    Nkx1-1 NK1 homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298981, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nkx1-1provided by RGD
    Official Full Name
    NK1 homeobox 1provided by RGD
    Primary source
    RGD:1564874
    See related
    EnsemblRapid:ENSRNOG00000005113 AllianceGenome:RGD:1564874
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564874
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system process; regulation of generation of precursor metabolites and energy; and regulation of glucose metabolic process. Predicted to be active in nucleus. Orthologous to human NKX1-1 (NK1 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Nkx1-1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81521206..81524788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77296676..77300575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82603538..82607031)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 53, member A Neighboring gene proteasome 20S subunit beta 3, pseudogene 5 Neighboring gene UV-stimulated scaffold protein A Neighboring gene uncharacterized LOC134481860 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    NK1 transcription factor-related protein 1
    Names
    NK1 transcription factor related, locus 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81521206..81524788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_234082.9XP_234082.6  NK1 transcription factor-related protein 1

      See identical proteins and their annotated locations for XP_234082.6

      UniProtKB/TrEMBL
      M0R5R8
      Related
      ENSRNOP00000064746.3, ENSRNOT00000073177.4
      Conserved Domains (1) summary
      pfam00046
      Location:295347
      Homeobox; Homeobox domain