Hcar2 hydroxycarboxylic acid receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hcar2provided by RGD
Official Full Name: hydroxycarboxylic acid receptor 2provided by RGD
Primary source: RGD:727952
See related: EnsemblRapid:ENSRNOG00000071408 AllianceGenome:RGD:727952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hm74; Hm74b; Pumag; Niacr1; rHM74b; Gpr109a; Gpr109b
Summary: Enables nicotinic acid receptor activity. Involved in negative regulation of lipid catabolic process and positive regulation of adiponectin secretion. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Orthologous to several human genes including HCAR2 (hydroxycarboxylic acid receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38387163..38389149)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32726252..32728238)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38160464..38161546)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1).
Title: Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1).
Data indicate that GPR109a modulates niacin-induced pancreatic islet dysfunction through activation of the islet beta-cells.
Title: Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.
HM74b has high similarity to HM74 is a receptor for nicotinic acid
Title: Molecular identification of nicotinic acid receptor.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Rat47 (e-PCR), detects polymorphism
- UniSTS:118840

BI294736 (e-PCR)
- UniSTS:246117

D4Rat40 (e-PCR), detects polymorphism
- UniSTS:227834

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables nicotinic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinic acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hydroxycarboxylic acid receptor 2

Names: G protein-coupled receptor 109B; G protein-coupled receptor Hm74b; G-protein coupled receptor 109; G-protein coupled receptor 109A; G-protein coupled receptor HM74; interferon-gamma inducible gene, Puma-g; niacin receptor 1; nicotinic acid receptor; protein PUMA-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181476.2 → NP_852141.1 hydroxycarboxylic acid receptor 2

See identical proteins and their annotated locations for NP_852141.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q80Z39

UniProtKB/TrEMBL

A6J130

Related

ENSRNOP00000098813.1, ENSRNOT00000156924.1

Conserved Domains (1) summary

cd15201
Location:25 → 302

7tmA_HCAR1-3; hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors