Phlda2 pleckstrin homology-like domain, family A, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phlda2provided by RGD
Official Full Name: pleckstrin homology-like domain, family A, member 2provided by RGD
Primary source: RGD:1304755
See related: AllianceGenome:RGD:1304755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in placenta development. Predicted to act upstream of or within several processes, including regulation of growth hormone activity; regulation of macromolecule metabolic process; and regulation of spongiotrophoblast cell proliferation. Predicted to be located in cytoplasm and membrane. Orthologous to human PHLDA2 (pleckstrin homology like domain family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 15.6), Liver (RPKM 4.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (208126302..208127241, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198696897..198699292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216701345..216704479, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Phlda2 (e-PCR), detects polymorphism
- UniSTS:516145

Tssc3 (e-PCR), detects polymorphism
- UniSTS:144693

NoName (e-PCR)
- UniSTS:532156

Phlda2 (e-PCR), detects polymorphism
- UniSTS:532156

RH130412 (e-PCR)
- UniSTS:213696

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glycogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth hormone activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pleckstrin homology-like domain family A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100521.1 → NP_001093991.1 pleckstrin homology-like domain family A member 2 isoform 1

See identical proteins and their annotated locations for NP_001093991.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0T2W6, A6HYC0, F1LME7

Conserved Domains (2) summary

smart00233
Location:12 → 102

PH; Pleckstrin homology domain

pfam00169
Location:12 → 102

PH; PH domain
NM_001170480.1 → NP_001163951.1 pleckstrin homology-like domain family A member 2 isoform 2

See identical proteins and their annotated locations for NP_001163951.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HYB9

Conserved Domains (1) summary

smart00233
Location:12 → 102

PH; Pleckstrin homology domain