Zdhhc11 zinc finger, DHHC-type containing 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc11provided by RGD
Official Full Name: zinc finger, DHHC-type containing 11provided by RGD
Primary source: RGD:1564281
See related: EnsemblRapid:ENSRNOG00000039743 AllianceGenome:RGD:1564281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf399; Zdhhc20
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity and signaling adaptor activity. Predicted to be involved in antiviral innate immune response; positive regulation of defense response to virus by host; and protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC11 (zinc finger DHHC-type containing 11) and ZDHHC11B (zinc finger DHHC-type containing 11B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 19.6) See more
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Genomic context

Location:: 1p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31124900..31156075, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29296334..29327227, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (31906049..31936603, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable palmitoyltransferase ZDHHC11

Names: DHHC-containing protein 10; membrane-associated DHHC11 zinc finger protein; zinc finger, DHHC domain containing 11

NP_001034431.2

EC 2.3.1.225

NP_001406430.1

EC 2.3.1.225

XP_038942712.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039342.3 → NP_001034431.2 probable palmitoyltransferase ZDHHC11 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q2TGJ8

Related

ENSRNOP00000094386.2, ENSRNOT00000117184.2

Conserved Domains (1) summary

pfam01529
Location:128 → 282

zf-DHHC; DHHC palmitoyltransferase
NM_001419501.1 → NP_001406430.1 probable palmitoyltransferase ZDHHC11 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1M6X9, Q2TGJ8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31124900..31156075 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086784.2 → XP_038942712.1 probable palmitoyltransferase ZDHHC11 isoform X1

UniProtKB/TrEMBL

Q2TGJ8

Related

ENSRNOP00000057691.5, ENSRNOT00000060971.5

Conserved Domains (1) summary

pfam01529
Location:123 → 294

DHHC; DHHC palmitoyltransferase