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    gdi-1 Rab GDP dissociation inhibitor [ Caenorhabditis elegans ]

    Gene ID: 178402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gdi-1
    Official Full Name
    Rab GDP dissociation inhibitor
    Primary source
    WormBase:WBGene00001558
    Locus tag
    CELE_Y57G11C.10
    See related
    AllianceGenome:WB:WBGene00001558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in anchor cell. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1) and GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gdi-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (14790818..14792887, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene RRM domain-containing protein Neighboring gene Ubiquinone biosynthesis O-methyltransferase, mitochondrial Neighboring gene Protein BRICK1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1. Lee AY, et al. PLoS One, 2010 May 13. PMID 20498707, Free PMC Article
    2. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. Yin J, et al. J Cell Biol, 2017 Jun 5. PMID 28424218, Free PMC Article
    3. A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. Lohmer LL, et al. PLoS Genet, 2016 Jan. PMID 26765257, Free PMC Article
    4. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation. Gomez F, et al. Gene, 2012 Sep 10. PMID 22735617, Free PMC Article
    5. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. Poteryaev D, et al. EMBO J, 2007 Jan 24. PMID 17203072, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We also characterized a novel invadopodia regulator, gdi-1 (Rab GDP dissociation inhibitor), which mediates membrane trafficking. We show that GDI-1 functions in the anchor cell to promote invadopodia formation.
      Title: A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
    2. Genetic interactors of gdi-1, the orthologue of GDI1, a gene associated with mental retardation in human, were identified.
      Title: Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rab GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Rab GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rab GDP dissociation inhibitor
    NP_001041043.1
    • Confirmed by transcript evidence
    NP_001041044.1
    • Confirmed by transcript evidence
    NP_001255836.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14790818..14792887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047578.5 → NP_001041043.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBR1
      Conserved Domains (1) summary
      cl21454
      Location:1 → 434
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001047579.7 → NP_001041044.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041044.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2V4S2
      Conserved Domains (1) summary
      cl21454
      Location:1 → 449
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001268907.3 → NP_001255836.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P8A8
      Conserved Domains (1) summary
      cl21454
      Location:2 → 93
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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