cyn-3 Peptidyl-prolyl cis-trans isomerase 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyn-3
Official Full Name: Peptidyl-prolyl cis-trans isomerase 3
Primary source: WormBase:WBGene00000879
Locus tag: CELE_Y75B12B.5
See related: AllianceGenome:WB:WBGene00000879
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in mitochondrion and nucleus. Is expressed in excretory system. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyn-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (15189927..15190926)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y75B12B.5 (e-PCR)
- UniSTS:305753

Y75B12B.4 (e-PCR)
- UniSTS:307157

STS5-225 (e-PCR)
- UniSTS:242389

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidyl-prolyl cis-trans isomerase 3

NP_506751.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15189927..15190926

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074350.9 → NP_506751.1 Peptidyl-prolyl cis-trans isomerase 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506751.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52011

Conserved Domains (1) summary

cd01926
Location:4 → 169

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...