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    tag-120 Transmembrane BAX inhibitor motif-containing protein 4 [ Caenorhabditis elegans ]

    Gene ID: 179362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-120
    Official Full Name
    Transmembrane BAX inhibitor motif-containing protein 4
    Primary source
    WormBase:WBGene00006470
    Locus tag
    CELE_F40F9.2
    See related
    AllianceGenome:WB:WBGene00006470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in excretory system; neurons; and pharyngeal muscle cell. Orthologous to several human genes including GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-120 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (9707771..9709814, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RNA_ligase domain-containing protein Neighboring gene Protein her-1 Neighboring gene Protein lifeguard 1-like Neighboring gene tRNA wybutosine-synthesizing protein 2 homolog Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane BAX inhibitor motif-containing protein 4
    NP_505501.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9707771..9709814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073100.9 → NP_505501.1  Transmembrane BAX inhibitor motif-containing protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20241
      Conserved Domains (1) summary
      cd10428
      Location:21 → 241
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein
    Heading Accession and Version

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