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    gcy-27 Receptor-type guanylate cyclase gcy-27 [ Caenorhabditis elegans ]

    Gene ID: 191654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-27
    Official Full Name
    Receptor-type guanylate cyclase gcy-27
    Primary source
    WormBase:WBGene00001550
    Locus tag
    CELE_C06A12.4
    See related
    AllianceGenome:WB:WBGene00001550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in chemosensory behavior and sensory perception of bitter taste. Predicted to be active in plasma membrane. Is expressed in amphid neurons and head mesodermal cell. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-27 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (17432977..17436652, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene GSKIP domain-containing protein Neighboring gene ncRNA Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene RxLR effector protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity. Krzyzanowski MC, et al. PLoS Genet, 2013. PMID 23874221, Free PMC Article
    2. Invertebrates yield a plethora of atypical guanylyl cyclases. Morton DB. Mol Neurobiol, 2004 Apr. PMID 15126679
    3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
    4. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article
    5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-27
    NP_001255956.2
    • Partially confirmed by transcript evidence
    NP_001255957.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17432977..17436652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269027.3 → NP_001255956.2  Receptor-type guanylate cyclase gcy-27 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1P657, Q9XU42
      Conserved Domains (3) summary
      smart00044
      Location:366 → 556
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:394 → 578
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl21453
      Location:72 → 321
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001269028.2 → NP_001255957.2  Receptor-type guanylate cyclase gcy-27 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1P657, Q9XU42
      Conserved Domains (3) summary
      smart00044
      Location:383 → 573
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:411 → 595
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl21453
      Location:75 → 338
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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