lip-1 Dual specificity protein phosphatase lip-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lip-1
Official Full Name: Dual specificity protein phosphatase lip-1
Primary source: WormBase:WBGene00003043
Locus tag: CELE_C05B10.1
See related: AllianceGenome:WB:WBGene00003043
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of vulval development; and vulval cell fate specification. Located in plasma membrane. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; germ line; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to several human genes including DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lip-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (6842958..6846011)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline.
Title: Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline.
DPL-1 and EFL-1, but not LIN-35, promote the expression of a negative regulator of MPK-1, the MAP kinase phosphatase LIP-1.
Title: The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.
LIP-1 phosphatase is required for the normal extent of germline proliferation, and it controls germline proliferation by regulating MAP kinase activity.
Title: LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05B10.1 (e-PCR)
- UniSTS:313470

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of meiotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vulval cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dual specificity protein phosphatase lip-1

NP_001293707.1

Confirmed by transcript evidence

NP_501053.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6842958..6846011

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306778.3 → NP_001293707.1 Dual specificity protein phosphatase lip-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293707.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44128, V6CIV8

Conserved Domains (1) summary

cd14566
Location:185 → 321

DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
NM_068652.4 → NP_501053.2 Dual specificity protein phosphatase lip-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501053.2

Status: REVIEWED

UniProtKB/Swiss-Prot

V6CIV8

Conserved Domains (1) summary

cd00127
Location:185 → 322

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...