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    T22D1.3 CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 177457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T22D1.3
    Official Full Name
    CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase
    Primary source
    WormBase:WBGene00020682
    Locus tag
    CELE_T22D1.3
    See related
    AllianceGenome:WB:WBGene00020682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; non-striated muscle; seam cell; and tail. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T22D1.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (6913538..6917112)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Neighboring gene RuvB-like 2 Neighboring gene Transposase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase
    NP_001023395.1
    • Confirmed by transcript evidence
    NP_001293729.1
    • Confirmed by transcript evidence
    NP_001368380.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6913538..6917112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306800.3 → NP_001293729.1  Inosine-5'-monophosphate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLC6
      Conserved Domains (1) summary
      PTZ00314
      Location:16 → 518
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    2. NM_001028224.4 → NP_001023395.1  Inosine-5'-monophosphate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GZH3
      Conserved Domains (3) summary
      cd00381
      Location:31 → 513
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:118 → 248
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:16 → 530
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    3. NM_001380295.1 → NP_001368380.1  CBS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIZ1
      Conserved Domains (1) summary
      PTZ00314
      Location:1 → 334
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    RNA

    1. NR_131558.1 RNA Sequence

      Status: REVIEWED

    2. NR_131559.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZH3.2

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