smcl-1 Structural maintenance of chromosomes-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smcl-1
Official Full Name: Structural maintenance of chromosomes-like protein 1
Primary source: WormBase:WBGene00008085
Locus tag: CELE_C44C10.4
See related: AllianceGenome:WB:WBGene00008085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to be part of cohesin complex. Predicted to be active in nucleus. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See smcl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (11693464..11695753)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings identify a Structural Maintenance of Chromosomes (SMC)-like protein, SMCL-1 (C44C10.4), that binds to condensin subunits dpy-26, dpy-27 and dpy-28 and modulates condensin functions.
Title: An SMC-like protein binds and regulates Caenorhabditis elegans condensins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44C10.4 (e-PCR)
- UniSTS:321280

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Structural maintenance of chromosomes-like protein 1

NP_509956.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11693464..11695753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077555.7 → NP_509956.2 Structural maintenance of chromosomes-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509956.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18616

Conserved Domains (2) summary

cl25403
Location:8 → 123

ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain

cl25732
Location:112 → 520

SMC_N; RecF/RecN/SMC N terminal domain