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    rab-39 Ras-related protein rab-39 [ Caenorhabditis elegans ]

    Gene ID: 183941, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-39
    Official Full Name
    Ras-related protein rab-39
    Primary source
    WormBase:WBGene00004286
    Locus tag
    CELE_D2013.1
    See related
    AllianceGenome:WB:WBGene00004286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTP binding activity. Involved in positive regulation of response to oxidative stress. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and plasma membrane. Is expressed in head mesodermal cell; hypodermis; intestine; neurons; and rectal gland cell. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Orthologous to human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-39 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9321858..9322920, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene WD repeat and FYVE domain-containing protein 2 Neighboring gene ncRNA Neighboring gene Transmembrane protein 41 homolog Neighboring gene Dynamin-like GTPase OPA1, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response. Takenaka M, et al. Genes Cells, 2013 Mar. PMID 23294242
    2. Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Da Silva JD, et al. Mol Neurobiol, 2020 Mar. PMID 31797327
    3. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    4. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Kao G, et al. Cell, 2007 Feb 9. PMID 17289575
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab-39 directly interacts with rasf-1.
      Title: C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein rab-39
    NP_495984.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9321858..9322920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063583.4 → NP_495984.2  Ras-related protein rab-39 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495984.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18969
      Conserved Domains (2) summary
      cd04111
      Location:16 → 229
      Rab39; Rab GTPase family 39 (Rab39)
      smart00175
      Location:18 → 186
      RAB; Rab subfamily of small GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18969.2

    Gene LinkOut

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