eat-4 Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eat-4
Official Full Name: Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4
Primary source: WormBase:WBGene00001135
Locus tag: CELE_ZK512.6
See related: AllianceGenome:WB:WBGene00001135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in several processes, including glutamatergic synaptic transmission; positive regulation of backward locomotion; and regulation of male mating behavior. Predicted to be located in plasma membrane and presynapse. Predicted to be active in excitatory synapse and synaptic vesicle membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to several human genes including SLC17A7 (solute carrier family 17 member 7) and SLC17A8 (solute carrier family 17 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eat-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (9136887..9141827)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
Title: Human vesicular glutamate transporters functionally complement EAT-4 in C. elegans.

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General gene information

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Markers

ZK512.6 (e-PCR)
- UniSTS:313630

ZK512.7 (e-PCR)
- UniSTS:316308

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of turning behavior involved in mating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of backward locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to mechanical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Major facilitator superfamily (MFS) profile domain-containing protein;putative vesicular glutamate transporter eat-4

NP_001293625.1

Confirmed by transcript evidence

NP_499023.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9136887..9141827

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066622.6 → NP_499023.3 putative vesicular glutamate transporter eat-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499023.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P34644, Q9TZN7

Conserved Domains (2) summary

cd06174
Location:110 → 492

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:66 → 497

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
NM_001306696.3 → NP_001293625.1 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293625.1

Status: REVIEWED

UniProtKB/TrEMBL

S6DQ91

Conserved Domains (1) summary

cd17382
Location:52 → 471

MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters