ima-1 Importin subunit alpha-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ima-1
Official Full Name: Importin subunit alpha-1
Primary source: WormBase:WBGene00002072
Locus tag: CELE_T19B10.7
See related: AllianceGenome:WB:WBGene00002072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables nuclear import signal receptor activity. Involved in protein import into nucleus. Located in cytoplasm and nucleoplasm. Part of nuclear pore. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ima-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (11239705..11241779)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T19B10.7 (e-PCR)
- UniSTS:308055

T19B10.6 (e-PCR)
- UniSTS:310876

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Importin subunit alpha-1

NP_001379139.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11239705..11241779

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392611.1 → NP_001379139.1 Importin subunit alpha-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O44926, Q22560

Conserved Domains (2) summary

COG5064
Location:10 → 496

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:319 → 348

ARM; armadillo repeat [structural motif]