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    pis-1 BRCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pis-1
    Official Full Name
    BRCT domain-containing protein
    Primary source
    WormBase:WBGene00004031
    Locus tag
    CELE_T13F2.3
    See related
    AllianceGenome:WB:WBGene00004031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in programmed cell death. Part of MLL3/4 complex. Orthologous to human PAXIP1 (PAX interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pis-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (9791933..9796594, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FTH domain-containing protein Neighboring gene Putative RNA polymerase II transcriptional coactivator Neighboring gene Delta(5) fatty acid desaturase fat-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. Vandamme J, et al. PLoS Genet, 2012. PMID 22570628, Free PMC Article
    2. Transcriptional control of non-apoptotic developmental cell death in C. elegans. Malin JA, et al. Cell Death Differ, 2016 Dec. PMID 27472063, Free PMC Article
    3. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
    4. DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans. Hofmann ER, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760063
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRCT domain-containing protein
    NP_501748.1
    • Confirmed by transcript evidence
    NP_501749.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9791933..9796594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069348.7 → NP_501749.1  BRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94046
      Conserved Domains (3) summary
      smart00292
      Location:933 → 1013
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:832 → 897
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00533
      Location:613 → 692
      BRCT; BRCA1 C Terminus (BRCT) domain

    2. NM_069347.5 → NP_501748.1  BRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U370
      Conserved Domains (3) summary
      smart00292
      Location:935 → 1015
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:834 → 899
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00533
      Location:615 → 694
      BRCT; BRCA1 C Terminus (BRCT) domain
    Nucleotide Protein
    Heading Accession and Version

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