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    unc-16 JNK-interacting protein [ Caenorhabditis elegans ]

    Gene ID: 176349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-16
    Official Full Name
    JNK-interacting protein
    Primary source
    WormBase:WBGene00006755
    Locus tag
    CELE_ZK1098.10
    See related
    AllianceGenome:WB:WBGene00006755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in several processes, including defecation; egg-laying behavior; and regulation of JNK cascade. Located in axon; cell body; and cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to several human genes including MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    27
    Sequence:
    Chromosome: III; NC_003281.10 (9546258..9557450)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene DUF2975 domain-containing protein Neighboring gene ncRNA Neighboring gene Protein NATD1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking at C. elegans synapses. Brown HM, et al. Dev Neurobiol, 2009 Feb 1-15. PMID 19105215, Free PMC Article
    2. UNC-16/JIP3/sunday driver: a new cop on the organelle highway. Zheng Q, et al. Genetics, 2013 May. PMID 23633141, Free PMC Article
    3. UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons. Kulkarni SS, et al. Genetics, 2021 Nov 5. PMID 34740241, Free PMC Article
    4. Microtubule-dependent ribosome localization in C. elegans neurons. Noma K, et al. Elife, 2017 Aug 2. PMID 28767038, Free PMC Article
    5. UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport. Sure GR, et al. Sci Rep, 2018 Jun 12. PMID 29895958, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
      Title: UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
    2. UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
      Title: UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
    3. UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.
      Title: UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.
    4. Data show that mutants in UNC-16 and UNC-76 increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in neurons.
      Title: UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.
    5. Data reveal a new and unprecedented role for 2 synapse assembly proteins, SAD-1 and SYD-2, in mediating UNC-16's organelle transport regulatory function.
      Title: UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.
    6. an organelle gatekeeper model is suggested in which UNC-16 (JIP3/Sunday Driver) selectively inhibits the escape of Golgi and endosomal organelles from the axon initial segment.
      Title: An organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment.
    7. putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron
      Title: Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.
    8. These results support the possibility that UNC-16 acts as an adaptor that links kinesin-1 and dynein for anterograde transport of dynein, which mediates APL-1 retrograde transport.
      Title: The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein.
    9. unc-14 binds to kinesin-1 and unc-16 complex and regulates synaptic vesicle localization.
      Title: The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor complex adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JNK-interacting protein
    NP_001022981.1
    • Confirmed by transcript evidence
    NP_001122747.1
    • Confirmed by transcript evidence
    NP_001122748.1
    • Confirmed by transcript evidence
    NP_001255008.1
    • Confirmed by transcript evidence
    NP_001255009.1
    • Confirmed by transcript evidence
    NP_001293608.1
    • Confirmed by transcript evidence
    NP_001293609.1
    • Confirmed by transcript evidence
    NP_001293611.1
    • Partially confirmed by transcript evidence
    NP_001293612.1
    • Partially confirmed by transcript evidence
    NP_001293613.1
    • Partially confirmed by transcript evidence
    NP_001293614.1
    • Partially confirmed by transcript evidence
    NP_001293615.1
    • Partially confirmed by transcript evidence
    NP_001293616.1
    • Confirmed by transcript evidence
    NP_001293617.1
    • Confirmed by transcript evidence
    NP_001380131.1
    • Confirmed by transcript evidence
    NP_741263.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9546258..9557450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171221.7 → NP_741263.3  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741263.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34609
      Conserved Domains (4) summary
      pfam03286
      Location:186 → 287
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:6 → 159
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:363 → 417
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:314 → 382
      JIP_LZII; JNK-interacting protein leucine zipper II

    2. NM_001268079.4 → NP_001255008.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255008.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7LPE3, A7LPE4, C0P271, C7FZT6, P34609, Q95V72, S6EZN6, S6EZP3, S6F548, S6F556, S6FD02, S6FN04, S6FN08, S6FWP4, S6FWP6, U4MKU8
      Conserved Domains (4) summary
      COG1196
      Location:75 → 486
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09744
      Location:41 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:365 → 433
      JIP_LZII; JNK-interacting protein leucine zipper II
      pfam19056
      Location:788 → 1052
      WD40_2; WD40 repeated domain

    3. NM_001129276.3 → NP_001122748.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE4
      Conserved Domains (4) summary
      pfam03286
      Location:222 → 402
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:381 → 435
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:332 → 400
      JIP_LZII; JNK-interacting protein leucine zipper II

    4. NM_001027810.5 → NP_001022981.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34609
      Conserved Domains (4) summary
      pfam03286
      Location:222 → 402
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:381 → 435
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:332 → 400
      JIP_LZII; JNK-interacting protein leucine zipper II

    5. NM_001392177.1 → NP_001380131.1  JNK-interacting protein [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam09744
      Location:41 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam14075
      Location:414 → 468
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:365 → 420
      JIP_LZII; JNK-interacting protein leucine zipper II

    6. NM_001306680.3 → NP_001293609.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN04
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:338 → 406
      JIP_LZII; JNK-interacting protein leucine zipper II

    7. NM_001306685.3 → NP_001293614.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZP3
      Conserved Domains (3) summary
      pfam03286
      Location:241 → 342
      Pox_Ag35; Pox virus Ag35 surface protein
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:402 → 470
      JIP_LZII; JNK-interacting protein leucine zipper II

    8. NM_001306686.3 → NP_001293615.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN08
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:350 → 418
      JIP_LZII; JNK-interacting protein leucine zipper II

    9. NM_001306684.3 → NP_001293613.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD02
      Conserved Domains (2) summary
      pfam09744
      Location:42 → 195
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:344 → 412
      JIP_LZII; JNK-interacting protein leucine zipper II

    10. NM_001306682.3 → NP_001293611.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4MKU8
      Conserved Domains (2) summary
      pfam09744
      Location:6 → 159
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam16471
      Location:347 → 415
      JIP_LZII; JNK-interacting protein leucine zipper II

    11. NM_001268080.3 → NP_001255009.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7FZT6
      Conserved Domains (2) summary
      pfam15619
      Location:109 → 201
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:83 → 151
      JIP_LZII; JNK-interacting protein leucine zipper II

    12. NM_001306683.3 → NP_001293612.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F548
      Conserved Domains (2) summary
      pfam14075
      Location:183 → 237
      UBN_AB; Ubinuclein conserved middle domain
      pfam16471
      Location:134 → 202
      JIP_LZII; JNK-interacting protein leucine zipper II

    13. NM_001306687.3 → NP_001293616.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FWP6
      Conserved Domains (2) summary
      pfam15619
      Location:47 → 139
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:21 → 89
      JIP_LZII; JNK-interacting protein leucine zipper II

    14. NM_001306679.3 → NP_001293608.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZN6
      Conserved Domains (2) summary
      pfam15619
      Location:41 → 133
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam16471
      Location:15 → 83
      JIP_LZII; JNK-interacting protein leucine zipper II

    15. NM_001306688.3 → NP_001293617.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F556

    16. NM_001129275.4 → NP_001122747.1  JNK-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34609.4

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