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    cdc-5L Cell division cycle 5-like protein [ Caenorhabditis elegans ]

    Gene ID: 172639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdc-5L
    Official Full Name
    Cell division cycle 5-like protein
    Primary source
    WormBase:WBGene00008386
    Locus tag
    CELE_D1081.8
    See related
    AllianceGenome:WB:WBGene00008386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in head. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdc-5L in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (8491291..8495833)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Carn_acyltransf domain-containing protein Neighboring gene Zip homologous protein 2 Neighboring gene HTH OST-type domain-containing protein Neighboring gene Homeobox protein ceh-6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
    2. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    3. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell division cycle 5-like protein
    NP_492303.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8491291..8495833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059902.7 → NP_492303.1  Cell division cycle 5-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492303.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFC4
      Conserved Domains (4) summary
      smart00717
      Location:8 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11659
      Location:56 → 108
      SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
      pfam11831
      Location:397 → 590
      Myb_Cef; pre-mRNA splicing factor component
      pfam13921
      Location:11 → 71
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version

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