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    lgc-47 Ligand-gated ion channel 50 [ Caenorhabditis elegans ]

    Gene ID: 181193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgc-47
    Official Full Name
    Ligand-gated ion channel 50
    Primary source
    WormBase:WBGene00009799
    Locus tag
    CELE_F47A4.1
    See related
    AllianceGenome:WB:WBGene00009799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgc-47 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (9801081..9807662, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene LITAF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 12 Neighboring gene GTPase-activating protein rrc-1 Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locomotion modulates olfactory learning through proprioception in C. elegans. Zhan X, et al. Nat Commun, 2023 Jul 27. PMID 37500635, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ligand-gated ion channel 50
    NP_741878.1
    • Confirmed by transcript evidence
    NP_741879.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9801081..9807662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171757.8 → NP_741879.1  Ligand-gated ion channel 50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC54
      Conserved Domains (3) summary
      TIGR00860
      Location:40 → 400
      LIC; Cation transporter family protein
      pfam02931
      Location:39 → 245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:254 → 333
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_171756.4 → NP_741878.1  Ligand-gated ion channel 50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEX8
      Conserved Domains (3) summary
      TIGR00860
      Location:59 → 419
      LIC; Cation transporter family protein
      pfam02931
      Location:58 → 264
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:273 → 352
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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