nekl-2 Serine/threonine-protein kinase nekl-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nekl-2
Official Full Name: Serine/threonine-protein kinase nekl-2
Primary source: WormBase:WBGene00022631
Locus tag: CELE_ZC581.1
See related: AllianceGenome:WB:WBGene00022631
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in molting cycle and positive regulation of endocytosis. Predicted to be located in cytoplasm. Predicted to be part of serine/threonine protein kinase complex. Predicted to be active in nucleus. Is expressed in hypodermis. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nekl-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (6663161..6665160)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that several highly conserved proteins in the nematode Caenorhabditis elegans, NEKL-2 and NEKL-3, regulate clathrin-mediated endocytosis within the context of an intact developing organism and demonstrates that loss of NEKL functions leads to defects in LRP1/LRP2 endocytosis, a cargo that is physiologically relevant to molting.
Title: Control of clathrin-mediated endocytosis by NIMA family kinases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC581.1 (e-PCR)
- UniSTS:310388

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in molting cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein kinase nekl-2

NP_491914.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6663161..6665160

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059513.6 → NP_491914.1 Serine/threonine-protein kinase nekl-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491914.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01775

Conserved Domains (2) summary

smart00220
Location:4 → 267

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd08215
Location:3 → 267

STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase