nekl-3 Serine/threonine-protein kinase nekl-3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: nekl-3
Official Full Name: Serine/threonine-protein kinase nekl-3
Primary source: WormBase:WBGene00008956
Locus tag: CELE_F19H6.1
See related: AllianceGenome:WB:WBGene00008956
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in gonad development and molting cycle. Located in apical plasma membrane. Is expressed in hypodermis; nervous system; and vulva. Orthologous to several human genes including NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See nekl-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (12389632..12391474, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
Title: UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
Study shows that several highly conserved proteins in the nematode Caenorhabditis elegans, NEKL-2 and NEKL-3, regulate clathrin-mediated endocytosis within the context of an intact developing organism and demonstrates that loss of NEKL functions leads to defects in LRP1/LRP2 endocytosis, a cargo that is physiologically relevant to molting.
Title: Control of clathrin-mediated endocytosis by NIMA family kinases.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F19H6.1 (e-PCR)
- UniSTS:314081

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in molting cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Serine/threonine-protein kinase nekl-3

NP_510080.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12389632..12391474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077679.9 → NP_510080.2 Serine/threonine-protein kinase nekl-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510080.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFM9

Conserved Domains (2) summary

smart00220
Location:23 → 279

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd08224
Location:23 → 283

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7