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    phlp-2 Protein phosphatase PHLPP-like protein [ Caenorhabditis elegans ]

    Gene ID: 185690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phlp-2
    Official Full Name
    Protein phosphatase PHLPP-like protein
    Primary source
    WormBase:WBGene00009647
    Locus tag
    CELE_F43C1.1
    See related
    AllianceGenome:WB:WBGene00009647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in neurons. Orthologous to several human genes including PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See phlp-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    18
    Sequence:
    Chromosome: III; NC_003281.10 (4209488..4216749)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase Neighboring gene RING-type domain-containing protein Neighboring gene Mitogen-activated protein kinase mpk-1 Neighboring gene Uncharacterized protein Neighboring gene Nuclear hormone receptor family member nhr-20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PHLPP1 regulates PINK1-parkin signalling and life span. Chandra K, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Aug. PMID 37060964
    2. BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1. D'Amora DR, et al. Cell Death Differ, 2018 Jul. PMID 29358669, Free PMC Article
    3. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein phosphatase PHLPP-like protein
    NP_001337270.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4209488..4216749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350391.3 → NP_001337270.1  Protein phosphatase PHLPP-like protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09564
      Conserved Domains (3) summary
      smart00332
      Location:754 → 985
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
      sd00033
      Location:289 → 311
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:283 → 718
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09564.3

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