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    cya-1 G2/mitotic-specific cyclin-A1 [ Caenorhabditis elegans ]

    Gene ID: 176287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cya-1
    Official Full Name
    G2/mitotic-specific cyclin-A1
    Primary source
    WormBase:WBGene00000863
    Locus tag
    CELE_ZK507.6
    See related
    AllianceGenome:WB:WBGene00000863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in meiotic cell cycle. Predicted to be part of cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1) and CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cya-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (9106699..9109272, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene Delta and osm-11 homolog protein 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordination of cell proliferation and cell fate determination by CES-1 snail. Yan B, et al. PLoS Genet, 2013 Oct. PMID 24204299, Free PMC Article
    2. Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression. Kreutzer MA, et al. J Cell Sci, 1995 Jun. PMID 7545687
    3. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. van der Voet M, et al. Cell Cycle, 2009 Dec 15. PMID 19829076, Free PMC Article
    4. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Cowan CR, et al. Nat Cell Biol, 2006 Dec. PMID 17115027
    5. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Shirayama M, et al. Curr Biol, 2006 Jan 10. PMID 16343905

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G2/mitotic-specific cyclin-A1
    NP_499018.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9106699..9109272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066617.10 → NP_499018.1  G2/mitotic-specific cyclin-A1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34638
      Conserved Domains (2) summary
      pfam00134
      Location:215 → 338
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:343 → 459
      Cyclin_C; Cyclin, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34638.2

    Gene LinkOut

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