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    H14N18.4 Gamma-glutamyltranspeptidase 1 [ Caenorhabditis elegans ]

    Gene ID: 179271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H14N18.4
    Official Full Name
    Gamma-glutamyltranspeptidase 1
    Primary source
    WormBase:WBGene00019204
    Locus tag
    CELE_H14N18.4
    See related
    AllianceGenome:WB:WBGene00019204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1); GGT2P (gamma-glutamyltransferase 2, pseudogene); and GGT3P (gamma-glutamyltransferase 3 pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See H14N18.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (8923845..8928978, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF2726 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-glutamyltranspeptidase 1
    NP_001343850.1
    • Confirmed by transcript evidence
    NP_001343851.1
    • Confirmed by transcript evidence
    NP_001367934.1
    • Confirmed by transcript evidence
    NP_001370776.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8923845..8928978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356716.3 → NP_001343850.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C326
      Conserved Domains (1) summary
      pfam01019
      Location:120 → 636
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001380718.2 → NP_001367934.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WIT0
      Conserved Domains (1) summary
      pfam01019
      Location:90 → 614
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. NM_001383361.1 → NP_001370776.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0B7
      Conserved Domains (1) summary
      pfam01019
      Location:120 → 644
      G_glu_transpept; Gamma-glutamyltranspeptidase

    4. NM_001356718.4 → NP_001343851.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C375
      Conserved Domains (1) summary
      pfam01019
      Location:90 → 606
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein
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