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    tnc-2 Troponin C [ Caenorhabditis elegans ]

    Gene ID: 174612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tnc-2
    Official Full Name
    Troponin C
    Primary source
    WormBase:WBGene00006583
    Locus tag
    CELE_ZK673.7
    See related
    AllianceGenome:WB:WBGene00006583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables troponin I binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in pharynx. Orthologous to human CALML6 (calmodulin like 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tnc-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (10466852..10468358)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene VWFA domain-containing protein Neighboring gene Pepsin-I3 domain-containing protein Neighboring gene Spore coat protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
    2. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
    3. Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system. Ono K, et al. Mol Biol Cell, 2004 Jun. PMID 15064356, Free PMC Article
    4. Cell-specific proteomic analysis in Caenorhabditis elegans. Yuet KP, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691744, Free PMC Article
    5. Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight. Higashibata A, et al. J Exp Biol, 2006 Aug. PMID 16888068

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables troponin I binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Troponin C
    NP_496251.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10466852..10468358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063850.6 → NP_496251.1  Troponin C, isoform 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09665
      Conserved Domains (2) summary
      PTZ00184
      Location:10 → 157
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:96 → 158
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09665.1

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