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    rab-28 Ras-related protein Rab-28 [ Caenorhabditis elegans ]

    Gene ID: 189429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-28
    Official Full Name
    Ras-related protein Rab-28
    Primary source
    WormBase:WBGene00004281
    Locus tag
    CELE_Y11D7A.4
    See related
    AllianceGenome:WB:WBGene00004281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Involved in several processes, including axoneme assembly; locomotory exploration behavior; and regulation of cilium assembly. Located in several cellular components, including ciliary base; ciliary transition zone; and periciliary membrane compartment. Is expressed in neurons and in male. Used to study ciliopathy. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-28 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (9242074..9244012, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene UNC93-like protein MFSD11 Neighboring gene DUF148 domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Akella JS, et al. Elife, 2020 Feb 26. PMID 32101165, Free PMC Article
    2. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. Jensen VL, et al. PLoS Genet, 2016 Dec. PMID 27930654, Free PMC Article
    3. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Kaletsky R, et al. Nature, 2016 Jan 7. PMID 26675724, Free PMC Article
    4. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    5. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Kao G, et al. Cell, 2007 Feb 9. PMID 17289575

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding.
      Title: Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding.
    2. our findings present a new approach for identifying ciliary proteins, and unveil RAB28, a GTPase most closely related to the BBS protein RABL4/IFT27, as an IFT-associated cargo with BBSome-dependent cell autonomous and non-autonomous functions at the ciliary base.
      Title: Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amphid sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein Rab-28
    NP_501609.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9242074..9244012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069208.3 → NP_501609.1  Ras-related protein Rab-28 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      I7EVL1, Q9XWR6
      Conserved Domains (1) summary
      cd04109
      Location:36 → 248
      Rab28; Rab GTPase family 28 (Rab28)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWR6.1

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