U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dnj-28 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171870, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dnj-28
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001046
    Locus tag
    CELE_Y54E10BL.4
    See related
    AllianceGenome:WB:WBGene00001046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable misfolded protein binding activity and protein-folding chaperone binding activity. Acts upstream of or within PERK-mediated unfolded protein response. Predicted to be active in endoplasmic reticulum. Is expressed in head; hypodermis; intestine; and tail. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dnj-28 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (2996488..3001382)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene small monomeric GTPase Neighboring gene SUPpressor of Rpm-1 Neighboring gene NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Neighboring gene CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone Neighboring gene Dual specificity mitogen-activated protein kinase kinase mek-2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones. Shemesh N, et al. Nat Commun, 2021 Apr 12. PMID 33846299, Free PMC Article
    2. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. Gaiser AM, et al. J Mol Biol, 2009 Aug 21. PMID 19559711
    3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within PERK-mediated unfolded protein response HEP PubMed 
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    J domain-containing protein
    NP_491084.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2996488..3001382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058683.5 → NP_491084.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3E0
      Conserved Domains (6) summary
      COG0484
      Location:378 → 445
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:28 → 52
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:380 → 445
      DnaJ; DnaJ domain
      pfam00515
      Location:31 → 56
      TPR_1; Tetratricopeptide repeat
      pfam13371
      Location:78 → 136
      TPR_9; Tetratricopeptide repeat
      pfam13414
      Location:23 → 89
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools