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    ntl-11 CCR4-NOT transcription complex subunit 11;Secreted protein [ Caenorhabditis elegans ]

    Gene ID: 178432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntl-11
    Official Full Name
    CCR4-NOT transcription complex subunit 11;Secreted protein
    Primary source
    WormBase:WBGene00013530
    Locus tag
    CELE_Y73F8A.25
    See related
    AllianceGenome:WB:WBGene00013530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulatory ncRNA-mediated gene silencing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT11 (CCR4-NOT transcription complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntl-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (15455127..15471494, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PAN-3 domain-containing protein Neighboring gene General transcription factor IIH subunit 4 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene 2Fe-2S ferredoxin-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
    2. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 11;Secreted protein
    NP_001122830.1
    • Confirmed by transcript evidence
    NP_001294106.1
    • Confirmed by transcript evidence
    NP_001294107.1
    • Confirmed by transcript evidence
    NP_001294108.1
    • Confirmed by transcript evidence
    NP_001367046.1
    • Confirmed by transcript evidence
    NP_502860.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15455127..15471494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307177.4 → NP_001294106.1  CCR4-NOT transcription complex subunit 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BTL9
      Conserved Domains (1) summary
      pfam10155
      Location:427 → 555
      DUF2363; Uncharacterized conserved protein (DUF2363)

    2. NM_070459.5 → NP_502860.2  CCR4-NOT transcription complex subunit 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502860.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA34
      Conserved Domains (1) summary
      pfam10155
      Location:427 → 555
      DUF2363; Uncharacterized conserved protein (DUF2363)

    3. NM_001307179.3 → NP_001294108.1  Secreted protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BPK7

    4. NM_001307178.3 → NP_001294107.1  CCR4-NOT transcription complex subunit 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BS59
      Conserved Domains (1) summary
      pfam10155
      Location:33 → 161
      DUF2363; Uncharacterized conserved protein (DUF2363)

    5. NM_001380548.1 → NP_001367046.1  CCR4-NOT transcription complex subunit 11 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0Y8
      Conserved Domains (1) summary
      pfam10155
      Location:110 → 238
      DUF2363; Uncharacterized conserved protein (DUF2363)

    6. NM_001129358.3 → NP_001122830.1  CCR4-NOT transcription complex subunit 11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HWB1
    Nucleotide Protein
    Heading Accession and Version

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