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    cnnm-3 Metal transporter cnnm-3 [ Caenorhabditis elegans ]

    Gene ID: 180591, updated on 9-Dec-2024

    Summary

    Official Symbol
    cnnm-3
    Official Full Name
    Metal transporter cnnm-3
    Primary source
    WormBase:WBGene00016343
    Locus tag
    CELE_C33D12.2
    See related
    AllianceGenome:WB:WBGene00016343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including intestine; nervous system; pharynx; rectum; and vulval muscle. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See cnnm-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (3036427..3045847, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Metal transporter cnnm-3
    NP_001309670.1
    • Confirmed by transcript evidence
    NP_001368594.1
    • Partially confirmed by transcript evidence
    NP_001370534.1
    • Confirmed by transcript evidence
    NP_001370952.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3036427..3045847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322613.3NP_001309670.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A131MBV5, A0A131MCZ8, A0A131MD56, Q21469
      Conserved Domains (2) summary
      pfam01595
      Location:199366
      DUF21; Domain of unknown function DUF21
      cl15354
      Location:398491
      CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    2. NM_001383538.1NP_001370534.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl40423
      Location:85112
      cupin_RmlC-like; RmlC-like cupin superfamily
    3. NM_001383539.1NP_001370952.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      COG1253
      Location:198491
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
    4. NM_001380926.1NP_001368594.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl40423
      Location:85112
      cupin_RmlC-like; RmlC-like cupin superfamily